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The 4 to 6 week break every 8 to 12 weeks is not optional

Ethical conduct of research The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations

10.1038/jcbfm.1990.117 79 HauserR

Abstract Extracellular glutathione peroxidase (E-GPx) is a selenium-dependent enzyme that can reduce hydrogen peroxide and phospholipid hydroperoxides