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Hypoxia-inducible factor 1 (HIF1) serves as a critical metabolic sensor in Th17 cells, and GLS1 is essential for Th17 differentiation and glycolysis promotion

The local effect theory suggests oral administration may actually work better than injection for these purposes

Moreover, by interacting with ALOX5, microsomal glutathione S-transferase 1 (MGST1) suppresses the ferroptosis and peroxidation of lipids (Zhang et al., 2023)

Further reactions of the oxysterols from both autoxidation and enzymatic routes can occur by oxidation or reduction, and they can be modified by many of the enzymes utilized for the metabolism of cholesterol and steroidal hormones, such as esterification and sulfation of position 3, as exemplified and illustrated here for 7-ketocholesterol

Bioresour Technol 290 , 121794 (2019) CrossRef PubMed Google Scholar 42.Jannel S, Caro Y, Bermudes M, Petit T, Novel Insights into the biotechnological production of Haematococcus pluvialis -derived astaxanthin: advances and key challenges to allow its industrial use as novel food ingredient[J]

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