In an inflammatory setting induced by IL-1, increased levels of hypoxia-inducible factor-2 (HIF-2) coupled with diminished GPX4 expression in chondrocytes increase their susceptibility to ferroptosis ( Figure 4 ) (80, 161)
In the high-dose treatment group, they reported statistically significant improvements in the total score, the motor subscore, and the non-motor subscore
Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-kappaB/ERK signaling pathway
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Tau protein is important for maintaining the stability of axonal microtubules involved in the mediation of fast axonal transport of synaptic constituents
Although metastasis has traditionally been viewed as a predominantly single-cell process driven by loss of adhesion, accumulating evidence shows that tumour cells can migrate and disseminate as cohesive clusters that retain cellcell contacts
