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A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

Figure 3 shows the synergistic positive feedback loop between ferroptosis and necroptosis, where ROS released during Erastin-induced ferroptosis triggers necroptosis, which in turn releases more ROS and iron to amplify the overall cell death signal

[DOI] [PubMed] [Google Scholar] 82.Liu Y S, Yuan M H, Zhang C Y et al