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These investigations, along with others, have contributed to the development of the current hypothesis for CBR distribution, which states that CB1 is largely found in brain and nearby structures like the pituitary (51) and peripheral nervous tissues (52), while CB2 is largely found in the immunological and reproductive systems

Indeed, several drugs derived from various natural sources, such as plants, marine organisms, and microorganisms, continue to successfully emerge (Torre and Albericio 2017