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As shown in Figure 2A, LDH levels in the culture medium were markedly increased in APP Swe/Ind -overexpressing cells treated with BSO compared to APP 695 cells under the same conditions

For decades, the predominant model in anticancer drug development has been the one target: one drug approach using small molecules or biologics [2]

Moreover, exposing mice to a low dose which reflects a typical American diet (0.01 mg/kg/day), caused gut microbiota alterations across two generations-consistent with earlier findings, Akkermansia muciniphila was depleted, while ParaBacteroides distasonis and Christensenellaceae were elevated in the second generation (Barnett et al., 2024)

Infect Immun (2022) 90:e0067221

For all these reasons, COPD remains a major worldwide health problem and global burden of disease studies have estimated COPD as the third leading cause of death worldwide [4]

For example, 2859% of patients with FMS that develop IBS, and 3277% of patients diagnosed with the diagnosis of IBS develop FMS during the course of their illness, with a relative risk increase of approximately 1.54-fold