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Support for this notion comes from instructive pathological feature found at the other end of the temporal spectrum, the so-called pre-active lesion, consisting of small clusters of activated microglia seen throughout the MS NAWM, accompanied by axonal and oligodendroglial injury (van Noort et al., 2011

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5.1 Qualitative evaluation To provide a qualitative and perceptual overview of the obtained results, we present a random snapshot of downscaled variables compared with both the input ERA5 low-resolution data and the COSMO-CLM high-resolution reference truth (Fig