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Conclusion Pregabalin treatment induced significant reproductive toxicity in rats, characterized by decreased body and testicular weights, increased oxidative stress, inflammation, and apoptosis, accompanied by disruption of the hypothalamic-pituitary-gonadal axis

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Whether this is clinically preferable to more frequent, pulse-preserving dosing with Mod GRF 1-29 depends on the treatment objective a point worth discussing with a prescribing clinician

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At this point, we have come full circle, showcasing the classic bench-to-bedside application of experimental evidence to establish a causal role for colonic epithelial H 2 O 2 in the pathogenesis of UC

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