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Lastly, a new diagnostic algorithm [H 2 FPEF score(Reddy et al., 2018)] that defines the most relevant clinical features (obesity, hypertension, atrial fibrillation, pulmonary hypertension, aging and diastolic dysfunction) of HFpEF has been recently developed (Figure 1)

EBioMedicine 7 , 240247 (2016)

and those with uncontrolled metabolic conditions should generally avoid peptide therapy unless specifically cleared by a specialist

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Therefore, in order to contextualize the complexity of the metabolic network and the impact of Gclc on it, we analyzed our transcriptomic data using Compass, a flux balance analysis-based approach that allows the characterization and interpretation of metabolic diversity at the single cell level 70,71

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