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Health 3 , 763771 (2025)

doi: 10.1128/mbio.02974-21 121 StutzM

254 Thalidomide is an immunomodulatory glutamate derivative that significantly reduces the protein expression levels of p-AKT and p-PI3K in intestinal epithelial cells and exerts anti-inflammatory effects by suppressing the activation of the PI3K/AKT pathway

thermodenitrificans where a homotetrameric precursor is initially produced, which underwent autocatalysis after incubation at 45C for 48 h ( Analysis of the recently solved crystal structure of the T399A precursor mimic of BlGGT gave interesting insights

C.LyoussiB.Quetin-LeclercqJ.MorelN

While mechanistically enigmatic, phenylacetylglutamines robust functional validation demands urgent mechanistic dissection to assess druggability, while serving as a caution against premature clinical extrapolation from correlative findings alone