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Wu C, Liu YE, Liu W, Zou T, Lu S, Zhu C, He L, Chen J, Fang L, Zou L (2023) NNMT-DNMT1 axis is essential for maintaining cancer cell sensitivity to oxidative phosphorylation inhibition

Free Radic Biol Med 145:819

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The selective mechanism that avoids systemic hormonal disruption suggests potential for extended use compared to interventions that create metabolic or endocrine imbalances requiring periodic breaks

Some practitioners extend titration even further for particularly sensitive individuals

Duration of Loading Phase The length of the loading phase varies