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KDIGO defines initial hyporesponsiveness as having no increase in hemoglobin concentration after the first month of appropriate weight-based dosing, and acquired hyporesponsiveness as requiring two increases in ESA doses up to 50 percent beyond the dose at which the patient had originally been stable

Vad DSIP r och varifrn det kommer DSIP r en liten nonapeptid: bara nio aminosyror, sekvens Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, med summaformeln C35H48N10O15 och en molmassa p cirka 848,8 g/mol (PubChem CID 68816, CAS 62568-57-4)

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