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1:12 yields remarkable antioxidant capacity (Mort et al., 2008[85])

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Together, these findings show that ESA induces ferroptosis as a single agent and distinguishes ESA from arachidonic and adrenic fatty acids, which sensitize cells to GPX4 inhibition but do not induce ferroptosis 13,17

Authors showed upregulation of transcripts related to inflammation, wounding and defence responses, complement and coagulation and cytokinecytokine receptor interaction pathways (24)

High levels of PUFAs are located in the outer photoreceptor segment and produce substantial amounts of intracellular ROS, making the retina especially susceptible to damage from oxidative stress (166) ( Figure 3 )