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Research findings: A 2003 study by Khavinson et al

Nat Rev Cancer 7 : 823833

This mesolimbic-cerebellar pathway forms a neuroanatomical interface between motivational-affective processing and cerebellar circuits, implicating the cerebellum in reinforcement learning and the drive for analgesia (5961)

They found that DDD therapeutically targets AS by enhancing mitochondrial function through the HIF-1 signaling pathway, reducing ROS levels, and modulating GPX4, Bcl2, and Bax protein levels, thereby benefiting AS and hyperlipidemia (Wu et al., 2023a)