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Collectively, this study provides a solid foundation for future exploration into the impact of NNMTi-and diet-mediated changes to the gut microbiome in obese and lean populations, as well as future targets to investigate mechanistically with NNMTi treatment

Adherence matters because missed doses can reduce benefit and complicate assessment, so clear schedules and reminders are useful

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Earlier monitoring, body-condition tracking, hydration awareness, antioxidant support, and daily cellular resilience may help support quality of life as cats age