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Haplotypes MS1 and MS3 were found to be the most prevalent

10.1016/s0006-8993(10)80047-2 53 HermansS

Tehran University Medical Journal TUMS Publications

Studies also in VEGFA-overexpressed human tumors and mouse tumor models revealed that apatinib plus PD-1/PD-L1 blockade therapy could alleviate hyperangiogenesis and hypoxia in TME and also alter the immunosuppressive TME into an immunostimulatory microenvironment [109]