glutathione and glutathione transdehygrogenase Synthase - an overview Schematic representation of the role

Rausch CR, Paul S, Montalban-Bravo G, Jabbour EJ, Daver NG, Alvarado Y, DiNardo CD, Ravandi F, Borthakur G, Bose P, Pemmaraju N, Naqvi K, Kornblau SM , Cortes JE, Kadia TM, Konopleva MY, Ohanian MN, Pierce SA, Gasior Y, Benton CB, Jain N, Takahashi K, Masarova L, Andreeff M, Estrov ZE, Kantarjian HM, Garcia-Manero G

In other words, DNMT mRNA expression changes occurred in specific cells in the brain tissue of depressed suicide patients 135

Nevertheless, astrocytes and other glia can also mediate detrimental effects in neurological disorders either through downregulation of essential functions or through gain of inappropriate functions such as promoting excess inflammation

Genes 11 , 1446 (2020)

105 ByndlossMDevkotaSDucaFNiessJHNieuwdorpMOrho-MelanderMet al

In response to oxidative stress, cGAS activation via STING drives the expression of senescence-associated secretory phenotype (SASP) factors, including TNF-, IL-6, CXCL2, CXCL10, CCL3, and CCL5