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In addition to COX , NRF2 is widely involved in the regulation of the expression of other OXPHOS-related nuclear genes, including three of the four subunits of succinate dehydrogenase ( SDH , complex II) and mitochondrial transcription factors ( TFAM and TFB1/2M )

While these changes are not well characterized in the literature, they represent hypothetical contributing factors to the subjective taste alterations patients report

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In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

Further research is needed to elucidate the mechanisms by which NNMT operates in MetS and to develop therapeutic strategies targeting NNMT