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van de Wal et al, 1998)

These reactions are required for the synthesis of purine and pyrimidine bases, inter-conversion of glycine and serine, biosynthesis of methionine methyl groups and degradation of histidine

Tylenol use during pregnancy appears to be one piece of this larger environmental puzzle.[] THE TIMELINE: TYLENOL INTRODUCTION AND RISING NEURODEVELOPMENTAL DISORDER RATES The temporal correlation between widespread acetaminophen use and neurodevelopmental disorder prevalence is striking: ACETAMINOPHEN INTRODUCTION AND ADOPTION[] 1955: Tylenol (acetaminophen) introduced for clinical use in the United States 1960s-1970s: First use in pregnancy for pain and fever management 1980s: Widely recommended as first-line agent for pain and fever in pregnancy Late 1980s-1990s: Increased use for post-vaccination symptom management in infants (replacing aspirin due to Reyes syndrome concerns) 2000s-present: Routine use in newborns/infants after vaccination

Journal of Molecular Endocrinology

Basu N, Clarke E, Green A, Calys-Tagoe B, Chan L, Dzodzomenyo M, Fobil J, Long RN, Neitzel RL, Obiri S (2015) Integrated assessment of artisanal and small-scale gold mining in Ghanapart 1: human health review