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Shelise Edwards, MD, FACEP

Regulatory history: Sermorelin was FDA-approved in 1997 under the brand name Geref for the treatment of growth hormone deficiency in children

Growth hormone plays a crucial role in collagen synthesis and tissue regeneration

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burgeoning industry's future uncertain"

Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines