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Banhegyi G., Lusini L., Puskas F., Rossi R., Fulceri R., Braun L., Mile V., Simplicio P., , Mandl J., Benedetti A

Actual results may vary

Notably, inhibition of MAPK/ERK signalling exacerbates 3-HK-induced mitochondrial dysfunction and cell death, implicating impaired cellular resilience pathways in amplifying KYN-mediated toxicity

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Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The inhibition was described as mild-to-moderate, not equivalent to a strong inhibitor like ketoconazole