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Regarding chronic exposure, cases of cardiac fibrosis [91], increased cardiac inflammation [92], and enlarged left ventricle [84] have been identified in preclinical models exposed to e-cigarette aerosol for three to eight months

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[91] Likewise, multiple reviews of internal tobacco company documents have found that flavored cigarettes are deliberately introduced to appeal to young people, with flavorings often being fine-tuned to best appeal to youth

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