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NADPH oxidase (NOX) and dual oxidase (DUOX) are the main sources of ROS in the gut, and the ROS they produce play an important role in maintaining intestinal homeostasis and antimicrobial defense

Additionally, M1 macrophages and N1 neutrophils produce Th1 and Th17 cell-attracting chemokines (C-X-C motif ligand (CXCL)-9/-10, C-C motif ligand (CCL)-20), enabling massive influxes of CD4+ and CD8+ Th1 and Th17 cells in inflamed eyes of DED patients [52]