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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)

Nemeth, Iron homeostasis in host defence and inflammation

22 Incidence, severity, and risk factors Paclitaxel appears to be more neurotoxic than docetaxel with an overall incidence of about 60% and 15% for each agent, respectively

Lifestyle modifications, stress management, proper nutrition, regular exercise, and addressing underlying risk factors through integrative medicine substantially reduce recurrence risk

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