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Additionally, Rh4 elevated ROS accumulation, which activatedROS/p53 signaling pathway, thus demonstrating that Rh4 inhibits proliferation of cancer cell via promoting the ROS/p53 signaling pathway and inducing ferroptosis through autophagy (75)

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LC is also found to serve as precursor for the generation of trimethylamine-N-oxide (TMAO) via a multistep metaorganismal gut microbiota-dependent pathway 39 (Fig

nitric oxide is increased in the brain by fluoxetine

Beneficial effect of low-dose systemic retinoid in combination with topical tretinoin for the treatment and prophylaxis of premalignant and malignant skin lesions in renal transplant recipients