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It is important to note that B12 levels should ideally be measured before commencing replacement therapy, as supplementation rapidly normalises biochemical markers, potentially obscuring the diagnosis

In the alternative pathway, StARD1, a mitochondrial cholesterol transporter, and CYP27A1 limit mitochondrial oxysterol synthesis

PLoS ONE 11(7):e0158779 Reddy DS (2023) Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies

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Univariate analysis To define the effect of drug exposure over 4 weeks and 8 weeks of treatment, linear mixed effects models (using the R package nlme 52 ) were fitted on each metabolite adjusting for age, gender, and HRSD 17 scores at baseline with subjects as random variable