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Lipid peroxidation occurs during IBD inflammation when ROS are not neutralized, altering the permeability and selectivity of the cell membrane and the activity of transmembrane transporters, receptors, and enzymes ( Supplementary Table 1 )

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19 MGST2 trimer structures limit catalysis to one active site at a time, and the biconical central pore modulates hydrophobicity, regulating solvent influx to optimize reaction conditions at the active site

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