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13 , 14 Furthermore, HBV elevates HIF2 expression by engaging its encoded protein, HBx, in binding with von HippelLindau protein (pVHL), thereby activating the nuclear factor kappaB (NFB) signalling pathway

Available at: Accessed 7/18/2011

However, production is costly, requiring specialized equipment like homogenizers and techniques such as microfluidization and ultrasonication

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In an in vitro study on human keratoconic stromal cells (keratoconus is an eye disorder that oxidative stress may be implicated in its development), an increased gene expression of antioxidant enzymes (SOD, GPx and CAT) in riboflavin-treated cells (compared with untreated cells) was reported (Reference Cheung, McGhee and Sherwin39)