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Specific mechanisms regarding how these mutations regulate the activity of GDH are unclear

Analyses using the Broad Institutes Connectivity Map suggest GHK may regulate more than 4,000 human genes, resetting aging-associated patterns toward profiles characteristic of younger tissue.23 In human plasma, GHK concentrations decline from approximately 200 ng/mL at age 20 to roughly 80 ng/mL by age 60a decline coinciding with the noticeable decrease in regenerative capacity that every aging athlete experiences firsthand