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Phase 2 trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) reported mean weight reductions of up to approximately 24% over 48 weeks in adults with obesity notably higher than results seen with currently approved agents

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It is widely assumed that metabolic detoxification mechanisms in insects are energetically expensive 32,33 , however, the absence of evidence for costs has also been reported 34,35

doi: 10.1007/s13312-021-2340-1 96 ShakooryBCarcilloJAChathamWWAmdurRLZhaoHDinarelloCAet al

Stryer L, Berg JM, Tymoczko JL (2002)

Lipotropics enhance this process by supporting the methylation reactions required to convert fat into transportable forms and by preventing hepatic lipid accumulation that can slow metabolic throughput