The preference for chewing and crushing may be linked to the ease of preparation and the availability of local tools, such as stones
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A buildup of porphyrin intermediaries has been found in various tissues and may induce the neuropsychiatric symptoms accompanying acute flareups
Lopez Guerra JL, Gomez DR, Lin SH, Levy LB, Zhuang Y, Komaki R, Jaen J, Vaporciyan AA, Swisher SG , Cox JD, Liao Z, Rice DC
HMGB1 stimulates inflammatory cytokine production and creates an inflammatory cascade, which tightly associates with increased mortality of sepsis (48, 49)

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