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Vitamin B3 (nicotinamide) was effective in ALS mice via Akkermansia , and now nicotinamide is being trialed in ALS patients at high doses to see if it slows progression [83, 267]

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Dysregulation of copper homeostasis interferes with the PARKIN/PINK1 pathway through multi-layered mechanisms (125)

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Patients experiencing persistent vomiting or diarrhea should be monitored for signs of dehydration and renal dysfunction, with appropriate fluid replacement and potentially temporary discontinuation of the medication if necessary

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Particle and Fibre Toxicology, 16 (1), Article 3

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Proc Natl Acad Sci 118:e2101708118

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