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There is a paucity of large well-powered studies to refute or confirm the exact benefit of the occurrence of irAEs during ICI therapy

Whichever test is used, the results must be interpreted along with the patients medical history in order to provide a formal diagnosis of the allergy

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Nonetheless, there remain significant limitations, such as the preclinical or in vitro nature of antiviral data, a large degree of interspecies pharmacokinetic disparity, and controlled clinical trials to support non-parasitic indications

After 6 h, blood was obtained by cardiac puncture into EDTA-containing tubes