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Antagonizing the EP1 receptors or agonizing EP4 may reduce kidney injury associated with growth/apoptosis, inflammation, oxidative stress, and fibrosis and control dysfunction in diabetic patients, thereby reducing the need for kidney replacement therapies (Nasrallah et al., 2016)

They're the difference between a compound that retains 95% potency at week 8 and one that's functionally inert by week 4, leaving researchers wondering why their IGF-1 didn't budge despite perfect protocol compliance

Aging Cell 13 , 1928 (2014)

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The effect of many drugs used to treat cancer also reflects a cumulative actioneg, the extent of binding of a drug to DNA is proportional to drug concentration and is usually irreversible