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In the conventional medical world, most vitamin deficiencies are taken as less serious than other medical conditions due to a variety of reasons (we wont talk about that today), despite the fact that replacing these nutrients can significantly improve symptoms in many patients

10.1088/1758-5082/3/3/034101 Biofabrication 89 XuJ.ZhangY.LiL.KongQ.ZhangL.GeS.et al (2018)

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To induce colitis, all groups except the NC group received 3.0% (w/v) dextran sulfate sodium (DSS) dissolved in sterile drinking water ad libitum for 7 days, while the NC group received sterile drinking water only

This effect is probably mediated by the MAPK/Erk1/2 pathway, whereby insulin stimulates the hypothalamus to secrete gonadotropin-releasing hormone (GnRH) ( 3.3 Advanced glycation end products AGEs can severely impair sperm function through multiple mechanisms