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Trends Cell Biol (2020) 30:47890

Comparative analysis of human mitochondrial methylomes shows distinct patterns of epigenetic regulation in mitochondria

The L66 mouse line, which overexpresses the full-length human tau with double mutations (P301S/G335D), demonstrates reduced nest building and sucrose preference at 5-6 months old, suggesting apathy-like deficits (Melis et al., 2015

suppressed T cell activity can hinder the clearance of damaged cells, fostering an inflammatory environment rich in oxidative stress that triggers ferroptosis in surrounding lung tissue (127)

Furthermore, iron and glutamate exhibit a close bidirectional regulatory relationship

Most of these selenoproteins contain selenocysteine in their active site, which exerts their antioxidant capacity through selenocysteine-catalyzed redox reactions 1