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In the United States, ME/CFS carries an annual economic burden of approximately $18 billion to $51 billion [13]

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This T cell homing impairment leads to a significant reduction in the number of effector T cells within the tumor, with only about 10% to 20% of T cells able to penetrate into the tumor parenchyma

Furthermore, stilbenoids downregulate COX-2 and iNOS expression, leading to decreased production of prostaglandin E2 (PGE2) and NO (Shi et al., 2017

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