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Finally, co-administration of bedaquiline with bupropion may cause an increased risk of hepatotoxicity, so it is better to avoid this association whenever possible, especially in patients who already have impaired liver function ( Possible interactions between antituberculous drugs and smoking cessation medications are summarised in Table 2

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Considering the cardiovascular system sensitivity and its non-linear dose-response/toxicity relationship with smoke, we sought to review the literature with regard to the effects of hookah on the cardiovascular system (see Fig

In addition, we contribute to the theorizing, in cognitive linguistics, of Pascuals key notion of fictive interaction (Pascual, 2002, 2014