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Gene mutations are another common mechanism of tamoxifen resistance, although there has been a number of mutations that are induced in vitro yet only very few of those mutations are observed in patients [46, 47]

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The surface modification of mesoporous silica particles (MSPs) reduces the hydrophobicity of EO, improves its solubility in the water phase, and enables it to penetrate into fungal cells, destroying the cell membrane and eventually causing cell death