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Chemico Biol Interact 292:7683

Since the 1990s, folate status and genetics have been linked to a plethora of diseases, many of which stem from impaired DNA-thymidylate and methylation pathways, and include adverse prenatal, oncogenic, cardiovascular and neurological outcomes

Which intracellular signalling pathways does IGF-1 LR3 activate via IGF-1R

10.1016/j.cell.2014.08.038 Cell 57 PetersonT

Thus, overactive mTORC1 inhibits mitophagy, leading to the accumulation of dysfunctional mitochondria, which contributes to increased ROS production and reduced cellular energy efficiency