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Bonnie Halpern-Felsher noted: "The GRAS designation means something is safe to consume through eating, or as a salve on the skin, but that's very different from heating a substance and inhaling the resulting aerosol." A 2022 study in the International Journal of Environmental Research and Public Health specifically examined this new category of "alternative flavored inhalable products" and flagged the lack of safety data, noting these products "have emerged which appear to capture users interested in" wellness-adjacent positioning

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