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Berberine inhibits cyclin activity by regulating PI3K/AKT, MAPK, and Wnt signaling pathways at the colon prelesion stage, thereby slowing down the cell cycle progression of polyp or adenoma cells [239]

Partial carboxyl deprotonation generates carboxylates, creating a surface potential of ~ 7 mV through balanced electrostatic repulsion and hydrophobic attraction that prevents excessive aggregation and ensures excellent colloidal stability

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Immunotherapies offer a more targeted approach, aiming to enhance the immune response against cancer cells while minimizing damage to normal cells [732]

Other glutathione delivery methods include: Oral liquid liposomal glutathione

In the kidney, CIS toxicity induced vacuolar degeneration in the glomerular capillary tuft and expansion of Bowmans space (Fig