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Lastly, ferroptosis can trigger systemic inflammatory response, activate multiple pro-inflammatory signaling, induce cardiomyocyte hypertrophy, fibrosis and death, and eventually lead to chronic adverse ventricular remodeling (Shirazi et al., 2017

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Similarly, recombinant PDI was diluted to 0.3 mg ml 1 in 100 mM sodium phosphate buffer (pH 7.0) containing 0.3 mM 1,8 ANS and thermal-shift assay was performed as described above

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10.1016/j.chembiol.2017.12.001 99 MizumuraK.CloonanS