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One unresolved question in ALS is why the neurons most susceptible to the altered/deficient EAAT2 (and neurodegeneration) come from two different populations which do not have much in common: The lower motor neurons in the spinal cord are cholinergic and project peripherally while the upper motor neurons are glutamatergic, excitatory, reside in the cerebral neocortex and target the brain stem and spinal cord (corticobulbar and corticospinal tracts)

Multiple organs are involved in CF, notably the lungs and pancreas

[PubMed 10048881] 2215

However, like any medical treatment, it should be performed after proper consultation and evaluation

Additionally, phenolic compounds have been shown to directly scavenge ROS, reducing oxidative stress

[DOI] [PubMed] [Google Scholar] Dissanayake, I