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Apart from the nitrogen mustards, several structural classes of alkylating agents are also of considerable interest, including the aziridines, hexitol epoxides, alkyl sulfonates, nitrosoureas, and the triazines/hydrazines, and these, together with the platinum-containing antitumor drugs, form the basis of this article

One or both drugs can potentially be used to target cholesterol metabolism which has been linked to GBMs invasive spread (Hamm et al., 2014