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At predetermined time points (0.5, 1, 2, 3, 4, 5, 6, 8, 10, 12, 24, 48, 72, 96, 120, and 168 h), 1 mL of the release medium was withdrawn and immediately replenished with 1 mL of fresh PBS

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It is important to note that BDNF levels in the serum and tears of glaucoma patients are significantly lower than in control subjects, suggesting that deficits in this neurotrophin may participate in RGC death in glaucoma (Oddone et al., 2017)

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FAO, 2020)

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