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However, long-term BG00011 exposure induced acute exacerbations and inflammation, leading to reduced survival rates, and the drug was ultimately discontinued from clinical development (Raghu et al., 2022b)

[Abstract]2024 May 28:590:216839

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Studies have shown that adding n-3 LCPUFA to TB treatment regimens reduced M.tb burden [50], decreased systemic and lung inflammation [51], and enhanced weight in M.tb -infected C3HeB/FeJ mice with a sufficient n-3 LCPUFA status [52]