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Skin aging is characterized by increased wrinkles, senile spots, dryness, thinning, and decreased elasticity ( Oxidative stress Skin aging and dermal damage are attributed to oxidative stress, which is a crucial factor ( Oxidative stress not only raises ROS production but also accelerates intrinsic skin aging due to a decline in cellular repair capacity associated with aging ( The impact of ROS particles relies on their dosage and duration, as well as the specific cells affected ( Furthermore, RNA is even more severely affected by ROS, resulting in reduced efficiency of translation and abnormal functioning of proteins and enzymes ( Different research studies have indicated that microbial elements may play a role in responding to oxidative stress ( Extracellular matrix degradation Wrinkle formation, drying, impaired wound healing, skin fragility, and muscle building are consequences of the changes in the structure of collagen, elastin, and glycosaminoglycan (GAG) in the extracellular matrix (ECM) as ages (40)

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(2020) 6:e05469

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