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p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3 E3 complex

Furthermore, MY-E@SS treatment systematically alleviated systemic oxidative stress in IBD mice, as indicated by increased serum levels of the antioxidant markers superoxide dismutase (SOD) and glutathione (GSH), and a decreased level of the lipid peroxidation product malondialdehyde (MDA) (Fig

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