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This is a significant phenotype, as a similar reduction in circulating triglycerides was not observed with a liver-specific loss of critical lipogenic enzymes, such as fatty acid synthase (FASN) 81

Kim BJ, Sung KC, Kim BS, Kang JH, Lee KB, Kim H, Lee MH

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Symptoms such as fatigue, mild abdominal discomfort, or loss of appetite may be dismissed as normal side effects rather than possible signs of liver stress

Targeted-capture next-generation sequencing in diagnosis approach of pediatric cholestasis

Significantly, Cyclin F contained a domain with sequence similarity to Cdc4, which they named the F-box domain